Guide Builder supports the Microsoft Active Accessibility (MSAA) compliant screen reader, JAWS for Windows from Freedom Scientific
To most effectively use the JAWS screen reader with a form guide, users must download and install scripts. These scripts enable some of the accessibility features of Flex and let users use the standard JAWS keyboard shortcut to enter Forms mode on a larger than usual set of user interface controls. It is important to direct users with visual impairments to these scripts (http://www.adobe.com/macromedia/accessibility/features/flex/jaws.html) so that they can use JAWS effectively.

Form guide support for screen readers